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Dietary supplement-based SOD cancer prevention provides another opportunity for antioxidant-based cancer prevention.[32] SOD mimetics have been shown to be beneficial in treating the currently incurable castration-resistant prostate cancer, in which SOD-2 expression is highly suppressed.[33] It has recently been shown that a potent SOD mimetic, MnTnBuOE-2-PyP(5+), enhances carbenoxolone-mediated TRAIL-induced apoptosis in the most malignant tumor of the brain.[34] SOD and inflammatory diseases Neutrophils play a central and essential role in the pathogenesis of inflammation